Applications
Cell
Metabolism
Easy to use kits measuring real-time energy flux, substrate utilization and mitochondrial function in living cells, without the need for expensive analysers.
Drug Safety
Toxicity
Advanced high throughput disease models and assays for early prediction of drug toxicity, mitochondrial liability and mechanistic characterization.
Hypoxia
Oxidative Stress
Measure and monitor oxygen throughout the cell culture workflow. Multiplex assays for intracellular / extracellular oxygen concentration and ROS.
New Study! Mitochondrial Function and Oxidative Stress in Cancer Research
A new study from researchers at the University of Windsor identified several highly active analogues of the natural compound Pancratistatin (PST). They found a combined treatment of cells with PST analogues and Piperlongumine, a compound known to induce the accumulation of ROS, significantly increase the apoptosis-inducing activity of the PST-analogues selectively in cancer cells. This combined targeting of mitochondrial and oxidative stress vulnerabilities will potentially alleviate adverse side-effects of current chemotherapeutics.
Stress Your Cells to See How They Are Really Feeling
Aerobic respiration is central to life. Oxygen consumption measurements are therefore a key parameter across biological research, providing a direct and specific measure of mitochondrial function and aerobic metabolism. While measurement of basal respiration alone is highly informative, it can be blind to underlying metabolic impairments or adaptations that do not reveal themselves under basal conditions. ‘Stressing’ the cells, however, can reveal these alterations allowing the identification of subtle mitochondrial impairment or increased metabolic capacity.
Luxcel Biosciences Ltd announce world first physiologically relevant, in vitro Ischemia-Reperfusion Model
Ischemia-reperfusion (IR) injury, occurs in the body when blood supply returns to tissues after a period of oxygen and nutrient deprivation. It is an important feature of several diseases including cardiac arrest, stroke and cancer, and is a critical consideration during transplantation. While significant advances have been made in understanding IR injury, progress has been impaired by i. the absence of a method to accurately and reproducibly replicate injury conditions in vitro, and ii. tools have not been available to quantitatively measure real-time cellular oxygenation in the ischemic cells.
Luxcel Biosciences Head of R&D to Present at Ncardia Applications Workshop
MetaCell partner Ncardia is hosting a 3-day Applications Workshop in Cologne, Germany. The workshop will focus on how researchers and laboratories can use their innovative iPSC-derived cardiomyocytes and neurons in various areas of drug discovery, development, and safety/ toxicity. Luxcel Biosciences Head of R&D James Hynes will give presentations and demonstrations on using cardiomyocytes to determine cellular Oxygen Consumption Rates and Fatty Acid Oxidation.
