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AACR-Shanghai-The-importance-of-cellular-oxygenation

The importance of cellular oxygenation measurements in the analysis of hypoxia-induced signalling and related metabolic adaptation.

M.Potter1, J.Hynes2, A.Nijhuis3, C.Carey2, I.Hayes2, C.Zois1, A.Harris1, H.Keun3, K.Morten1. 1.University of Oxford, UK 2. Luxcel Bioscience Ltd, Cork, Ireland 3. Imperial College London, UK.

Presented at American Association for Cancer Research, Shanghai China November 6-9 2017.

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drug-induced modulation of fatty acid oxidation

A functional high-throughput screen for drug-induced modulation of fatty acid oxidation.

Conn Carey1, Tang Xinru2, Yvonne Will3, James Hynes1 1Luxcel Biosciences, Cork, Ireland, 2HD Biosciences, Shanghai, P.R. China, 3Drug Safety R&D, Pfizer Inc., Groton, CT, USA.

Presented at Society of Toxicology Annual Meeting Baltimore USA 2017.

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Investigating Drug Induced Cardiomyocyte Dysfunction through Combined Analysis of Beating, Metabolic Flux and Cellular Oxygenati

Investigating Drug Induced Cardiomyocyte Dysfunction through Combined Analysis of Beating, Metabolic Flux and Cellular Oxygenation.

Conn Carey1, Cristina Bertinetti-Lapatki2, Ralf Kettenhofen3, Adrian Roth2, James Hynes1 1Luxcel Biosciences Ltd., Cork, Ireland, 2Pharmaceutical Sciences, Pharma Research & Early Development, Roche Innovation Centre, Basel, Switzerland, 3Axiogenesis Ltd., Cologne, Germany

Presented at Society of Toxicology Annual Meeting Baltimore USA 2017.

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High-throughput in vitro ischemia-reperfusion model

High-throughput in vitro ischemia-reperfusion model with real-time monitoring of cellular oxygenation and reactive oxygen species generation.

C. Carey1, R. Kettenhofen2, M. Schwalfenberg1, J. Hynes1 1Luxcel Biosciences Ltd., Cork, Ireland, 2Axiogenesis AG, Cologne, Germany

Presented at EMBL Metabolism in Time and Space Emerging Links to Cellular and Developmental Programs Heidelberg, Germany.

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